Antabuse, or disulfiram as it is also known, was the first medicine approved for the treatment of alcohol abuse and alcohol dependence by the U.S. Food and Drug Administration.

Antabuse (Disulfiram) is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a cure for alcoholism, but discourages drinking. more

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Never give Antabuse (disulfiram) to a patient in a state of alcohol intoxication or without the patient's full knowledge. The patient should not take disulfiram for at least 12 hours after drinking. A reaction may occur for up to 2 weeks after disulfiram has been stopped.

ANTABUSE (DISULFIRAM) can help patients with an alcohol abuse problem not to drink alcohol. When taken with alcohol, this medicine produces unpleasant effects. This medicine is part of a recovery program that includes medical supervision and counseling. It is not a cure. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You must never take this medicine within 12 hours of taking any alcohol. The tablets can be crushed and mixed with liquid before taking. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of the following conditions:

• brain damage
• diabetes
• heart disease
• kidney disease
• liver disease
• psychotic disease
• recently exposure to alcohol or any product that contains alcohol
• seizures
• taking metronidazole or paraldehyde
• under-active thyroid
• an unusual or allergic reaction to disulfiram, pesticides or rubber products, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

What may interact with this medicine?

Do not take this medicine with any of the following:

• alcohol or any product that contains alcohol
• amprenavir
• cocaine
• lopinavir; ritonavir
• metronidazole
• oral solutions of ritonavir or sertraline
• paclitaxel
• paraldehyde
• tranylcypromine

This medicine may also interact with the following:

• isoniazid
• medicines that treat or prevent blood clots like warfarin
• phenytoin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• changes in vision
• confusion, disorientation, irritability
• dark urine
• general ill feeling or flu-like symptoms
• loss of appetite, nausea
• loss of contact with reality
• numbness, pain or tingling
• right upper belly pain
• unusually weak or tired
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• change in sex drive or performance
• dizziness
• drowsy, tired
• headache
• metallic or garlic taste
• nausea, vomiting

This list may not describe all possible side effects.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Never take this medicine if you have been drinking alcohol. Make sure that family members or others in your household know about this medicine and what to do in an emergency. When this medicine is taken with even small amounts of alcohol, it will produce very unpleasant effects. You may get a throbbing headache, flushing, vomiting, weakness and chest pain. Breathing and heart problems, seizures and death can occur. This medicine can react with alcohol even 14 days after you take your last dose.

Never take products or use toiletries that contain alcohol. Always read labels carefully. Many cough syrups, liquid pain medications, tonics, mouthwashes, after shave lotions, colognes, liniments, vinegar's, and sauces contain alcohol.

Wear a medical identification bracelet or chain to say you are taking this medicine. Carry an identification card with your name, name and dose of medicine being used, and name and phone number of your doctor and/or person to contact in an emergency.

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